During the Japanese occupation before the liberation of Taiwan, Taipei had two independent professional organizations of medical practitioners, namely the Medical Association of Taipei City, established by the Japanese, and the Taipei Medical Association, established by Taiwanese physicians. After the liberation of Taiwan in August 1945, entrepreneur physicians of Taipei city immediately organized, and on October 18 of that same year, a general meeting was held after which the Taipei Medical Association was officially established. In April of 1946, registration of the Association was approved, thus becoming the first established civil organization of Taiwan. At the time, membership was voluntary and Dr. Lin Ching-yueh was the first president of the Association which then consisted of 104 members.

After establishment, various activities were introduced, such as promotion of the concept of 'respecting the old and honoring the virtuous' and appealing to the public to implement traditional moral values; in order to prevent the redirection of hospitals for other purposes, the authorities were requested to maintain hospital practices; the Medical Disputes Evaluation Committee was established; trips to Japan were made to examine its medical system, etc. Of course, much emphasis was placed on providing a service to the public and physicians. During reconstruction in the early days after liberation, the Association thus offered an indelible contribution to the social stability and public health.

On February 1, 1957, the Taipei Medical Association for the first time published the 'Taipei Medical Association Report', which was sent to all members each month. Its publisher was the tenth president of the Taipei Medical Association, Dr. Hung Lee-feng. In January 1979, the name of this publication, the Association's main outlet and medium for communication with members, was changed into the 'Bulletin of Taipei Medical Association'.

During the early days of establishment, the president's address was also used as the address of the Association, and whenever a new president was elected, the Association's address changed as well. Upon the eleventh president Chang Shao-lien's suggestion in 1960 that the Association should have its own headquarters, the Development Committee for a Taipei Medical Association Headquarters was formed in 1961, and 1.1 million in funds was collected from members in 6 months. Hsing Lin Co. Ltd. was founded and a five-storey building on Chunghwa road purchased. While property rights were assigned to Hsing Lin Co. Ltd., the Association took up headquarters on the third and fourth floors.

In July 1976, Dr. Wu Tsuo-jen took up his post of the Association's fourth president after Taipei was placed under the central government's direct jurisdiction. Again, a task force was established to plan the purchase of an Association headquarters, and after careful consideration and approval of the board of directors and supervisors, members' donations and contributions and the Association's shares of Hsing Lin Co. Ltd. were sold. With the resulting funds and the Association's other accumulated funds, the Association was able to purchase the sixth and seventh floors of the Tung Men Building located at No. 74, Hsinyi Road Section 2 (the Association's current address), for the sum of 5 million NT dollars.

Initially, association membership was voluntary, but after implementation of the physicians' law on September 11, 1975, it was stipulated that all certified physicians who practice in Taipei city must become members of the Taipei Medical Association, resulting in a sudden increase in members. As of begin 2003, membership totaled 7,304. The main objective of the Association is to service its members, to assist them in solving problems, and to fight for beneficial health policies and benefits for members and the public. To smoothen operations, 16 committees that each have their own responsibilities and that report to the board of directors have been established. These form the communication bridge between the Association and its members, the government and the public.

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